An Obscene Place

Western Oregon was a beautiful place in which to live. There were times I felt the country was so lovely it could be called “obscene.” After all, one of its definitions indicates that something may be so excessive as to be offensive. If one can possess “obscene wealth,” why can’t a place be so lovely that it is overly provocative.

Spring was abundant with its glorious bulbs of grape hyacinths in violets, purples and blues. Visions of rhododendron and roses were in every yard. The winter rains produced every shade of green that was physically possible. Native Oregonians waxed eloquently about the marvels of the state, until they suddenly realized that what they were saying might entice mere visitors to settle here. Suddenly, comments about constant rain and chills filled their reports. The warning, at the time, was: “Don’t Californicate Oregon!”

From time to time, we traveled north to Portland (and beyond to Seattle to visit dear friends, the Ritchies, who had moved there from Hanover), but we seldom went south to Salem, the capital city where OSU’s rival, the University of Oregon, was located. We found the Portland Zoo had its share of brown bears and polar bears. Deb liked to feed the giraffe which had the longest tongue we had ever seen. We also took my parents there when they made a two-day visit to Oregon. As was their custom, they would spend several days on a bus and sleep during their nighttime travel. They could not abide staying more than forty-eight hours, once they had arrived at their very temporary designation.

Karen, the kids and I also enjoyed driving into the Cascades to the east, but our favorite was to cross the Coastal mountains, even if one unwelcome sight was to see gray smoke rising from the sawmills burning off their waste lumber to make coke. Once on the Coast, we enjoyed camping among the Dunes of the Pacific Ocean. Although we would bring a small tent to pitch, our VW microbus made a cozy place to sleep. And without mosquitos! The entire time we lived in Oregon, we never saw or heard one of them. It was only when we returned to the East Coast that we and the kids ended up with multiple bites and itchy bumps from the buzzing critters.

We liked the sands of the Dunes between Coos Bay and Florence and had to get use to the rock-covered shores of the rest of the coastline. We thought it was innovative that the state of Oregon had designated the entire coastline as a public highway to preclude private housing from developing along the way and ruining the views.

On our trips westward we were amazed at how cold the northern Pacific Ocean remained until early September. It took courage to wade in the water in midsummer; swimming was not considered, since this was a time long before wetsuits became common, especially among surfers, a group that was little recognized in the sixties. Our Midwestern, landlocked background continued to control our behavior. We let the seals float by themselves in the cold foam of the Pacific Ocean.

The city of Corvallis was pleasant enough that we had no great desire to travel beyond its limits. Even though Karen did not drive at the time and did not require the use of our car, I often rode my bike between our house and the lab on campus. The land was flat and the distance short. On-campus parking was also limited. There were a lot of bike racks available.

During our first year, we were close enough to the downtown stores that Karen and the kids, by walking with a stroller, were able to investigate them without spending much other than their time. Our relationships with friends, except for a few young faculty members, were limited; none lived nearby. Our move from our old-fashioned house to a newer duplex away from downtown Corvallis did isolate us to some extent, but it did encourage us to spend more time together as a young family.

We were of a young and active enough age to hike the trails we discovered among very tall pine trees that had the most alluring fragrance found in nature. We had also learned the advantages of a papoose carrier. Deb and Ken saw much of the Northwest while moving backwards, strapped into aluminum devices that allowed Karen and me the freedom to reach out, to touch and to smell the roses.

Oriental Views

During my professional life I had significant collegial relationships with two biochemists of Asian ancestry: Lafayette Noda and Tsoo E. King. In personality they could not have been more different.

Lafayette was the Chairman of the Biochemistry Department at Dartmouth Med during the time I was a postdoctoral fellow with Lucile. He had taken an interest in me and urged me to continue my career in Hanover as an Instructor in his department. Tsoo was a Professor in the Department of Chemistry at Oregon State University and had lied to me about a faculty position there as an Assistant Professor. During my two years with him – an interval that seemed twice as long as my two years in New Hampshire – I was acutely aware that I was really, once more, a postdoctoral fellow with Dr. King as my supervisor.

Dr. Noda had a very interesting background. He was Nisei, a second-generation son who had been interred, along with his parents, relatives and other US-Japanese citizens, in camps in California, Wyoming and Colorado. The federal government believed such drastic action was necessary during the Second World War. At some point, he became a Quaker, and lived out his entire life in that peaceful calling. I have never met anyone so dedicated to peace and harmony as were Lafayette and his wife, Mayme. During the time we were living in Hanover, many people were involved in peaceful demonstrations regarding the Vietnam War. Lafayette and Mayme were often part of those quietly standing on the corner of the Hanover Commons on a weekend.

Their apologies about the skunk in their barn and the stench of our stuff that had been left there on our move to Hanover were truly profuse and deeply meant. Their hospitality was readily available to anyone in need. He and Mayme often invited us and faculty to his old New England house for gatherings and for meals. The Nodas are the only people I knew who, routinely, bought gallons of soy sauce and 25-pound sacks of rice. I recall one remarkable dinner when the guests were given the usual chopstick for their utensils. Everything went well until dessert was offered: cubes of red or green Jell-O! Lafayette did have a sense of humor; he relented when his guests observed that his own kids were now using spoons.

Lafayette died in February 2013, at the age of 96. I saw him on an occasional trip to the Federation meetings we attended. I wish I had known him better, personally.

Tsoo E. King was among the least trusting and most prevaricating scientists I’ve ever met. His deceit was more than just lying to me about my position in his department at OSU. Within a few days in Corvallis, I learned from the department chair that I was not really a faculty member in the Chemistry department, but merely a postdoc in the Science Research Institute. Although I did offer sections of the biochemistry class regarding lipids, my primary position was to undertake the laboratory work assigned to me by Dr. King. Our “team” consisted of a research associate, Bob Howard, and a graduate student, Jack Kittman. At least, with Tsoo, I did get three research papers published as first author in Biochemica Acta and the Journal of Biological Chemistry.

As his team, we were constantly cautioned not to discuss with anyone else anything occurring in the lab, whether the topic was the research, itself, or any other departmental event we might have heard about. His secretary, Clistie Stoddard, was the only person, other than King, himself, who had the key to the cabinet holding “fine chemicals,” which were expensive but vital to our work.

I was surprised when I learned that “Clistie” was actually “Clistie.” Tsoo had a very heavy Chinese accent, so I had assumed he was, once again, merely mispronouncing “Christy.” I often wondered how he had managed to find somewhat whose name he could actually handle.

Because of his accent, one of my jobs was to translate what he had said in the lectures he gave. I had a high interaction with graduate students taking classes with him. I also found it necessary to “de-Tsoo” all of his scientific writings by editing them into recognizable English while still leaving the essence of his Chinese orientation.

Working closely with Bob, King’s research associate, was one of the limited pleasurable events in my daily lab work. His only distraction involved Bell’s palsy, which gave him a ticking cheek. Jack Kittman, a graduate student, was the third member of our laboratory gathering. The only unexpected event in our lives was the day when Jack’s wife, who was also a graduate student and research assistant in our lab, entered long enough to say she had just taken cyanide. Her suicide was the only one I have ever known about directly. It devastated Jack and had an effect on all of us. Cyanide is the major inhibitor for the enzyme cytochrome oxidase and was used, routinely, in our research. In fact, the paper I published in Biochemica Acta bears the title: “The Effect of Cyanide on the Keilin-Hartree Preparation and Purified Cytochrome Oxidase.” Basic research and real life do have intersections, even unexpected ones.

Where Were You When?

There’s a difference between a “Where were you when …?” question and one that asks: “Do you remember when …?” A person can be asked: “Do you remember when the Challenger exploded?” or “Do you remember when Neil Armstrong stepped onto the moon?” The inquiry may be about a disaster or a great event in history, but they differ from the one which asks, “Where were you when the planes crashed into the World Trade Center?” Or the one about our first modern-day crisis: “Where were you when Kennedy was assassinated? In these “where-were-you-when” questions, there is a double focus: one on the crisis, itself, and a second on your own bodily reaction to the event; how the event impacted your own life more directly than you would have thought could be the case.

Where was I when JFK was killed?

I was working in the lab at Oregon State in Corvallis, a town a thousand miles from Dallas. Background music was playing on the small radio on a shelf in the lab. The news crackled forth and the lives of millions who heard the announcement at the same moment were dramatically changed. Was this another Orson Wells fantasy? Halloween had passed several weeks ago; thoughts now involved Thanksgiving, occurring within in a few days. Today was Friday, November 22, 1963, it was about 10:30 a.m. on the Pacific coast.

Other faculty, staff, and students wandering by were called into the lab to listen. To hear the impossible. To reject it and then, with extreme reluctance, to accept the possible truth of it. We whispered to one another. There were few tears; they came later. No one could stay and listen further. We each had to go home to loved ones.

I closed off what I was doing and, leaving the lab, got on my bike to pedal the half mile to my house. Had Karen heard the news? There were no others along the streets. No cars, no bikes, no pedestrians. Yet I wanted to shout to someone, anyone, “Have you heard?” But there were none to hear. When the two of us met, all we could do was hold on to one another as deeply as possible.

For the next week, we listened and watched events as they appeared on the recently established television networks of the country. Within 90 minutes, Lee Harvey Oswald was arrested in Dallas. Within 48 hours the accused assassin was, himself, shot in the Dallas Police Station. We began to hear about the “grassy knoll conspiracy” as we watched John-John salute his father’s casket and Jacqueline lead the Nation in its mourning of her murdered husband.

I do not recall the death of any other incumbent President. There was no other benchmark upon which to pin my observations and feelings. FDR had died in office, but, in 1945, I was only ten years old, probably in the fourth or fifth grade. That was so long ago, even in 1963, when the towers of Camelot came crumbling down.

I had admired JFK for many reasons. He and Jackie were a young couple, one whose family-life seemed as ideal as those who had, according to other legends, lived in that other magical kingdom of knights, where Arthur reigned, and Merlin advised. It was only later that the John-Jackie legend became tarnished by real-life peccadillos. In that terrible November, I thought more about how he had prevented a nuclear war than about his botched invasion at the Bay of Pigs. He had been the first, and until 2020, the only, Catholic elected President. His widespread intelligence was favorably compared with Jefferson’s. Then again, our third President’s life has undergone revisions by modern historians, as have those of all the others!

In that November, we watched the riderless horse and worried greatly about the future of our nation. We firmly believed no matter what had happened that this nation would survive. Little did anyone recognize what dramatic events would occur in the coming decades to impact on such thoughts.

At the time, I did not realize how the events happening in Washington, D.C. would affect my own life and career development. “Where was I when?” led directly, over time, to “where am I now?”

Hot Hymns

JFK was the first Catholic President. Without the changes of the Second Vatican Council in the early 1960’s one might wonder if a Catholic could ever have been elected to this office. Three decades earlier Alf Landon showed the difficulty to be encountered. There were, of course, many changes initiated within the Church during this era.

Although the major changes resulting from Vatican II were not really implemented until after its final session had been completed in December 1965, early liturgical changes were hinted at in the years before the closing event. One major expected change was in the language of the liturgy, itself. The Mass which had used Latin for almost two-thousand years might be translated into English and other vernacular tongues people actually spoke and understood.

The Pastor of the local Catholic parish in Corvallis was a musicologist, who had recently composed an English language Mass in anticipation of the possible liturgical change. The quartet from St. Mary’s Church had piled into our micro-bus for a brief journey to Portland where they were to perform this new liturgy for representatives from the Diocese of Portland. Karen had been an active member of the group; I was merely the driver. They may have been practicing their hymns as we drove along the new Interstate highway heading north from Corvallis.

In my rearview mirror I suddenly noticed a cloud of gray smoke pouring from the exhaust pipe of our micro-bus and I quickly pulled over to the side of the highway. We all got out to see what was happening to my relatively new vehicle. What better way to find the origin of the smoke than to open the door to the engine compartment in the rear of the wagon. That was the wrong move. With exposure to more oxygen, bright flames burst forth to engulf the entire motor. We all scurried away before the small explosion occurred. All four tires burst from the heat and the vehicle settled onto the pavement where it slowly burned down to its metal framework.

This was long before the invention of cellphones, but many truckers did have two-way radios for routine communication along the highways they traveled. Fortunately, one of the passing truckers had called the local voluntary fire department. The volunteers arrived very quickly and put out the blaze. Arrangements were made to tow the remains of my micro-bus back to Corvallis. We pleasantly learned that many of the volunteers were also members of a local Knights of Columbus chapter. They kindly took us to their meeting hall to await the arrival of transportation for the choir back to St. Mary’s.

The adventure had mixed results. The next day when I went to see my insurance agent, he inquired if the event had happened on the Interstate at a particular time. My response corresponded with his recollection of his own trip the previous day along that route. Without the need for any further investigation, he was able to declare that there had been a complete loss of my wagon and I could expect a full reimbursement for the accident.

Officials in the transportation office of the University were less understanding of the situation. When I went to get a new parking sticker for the replacement vehicle, I was told I should have peeled off the old sticker and brought it to them before they could issue a replacement. I finally convinced them that the micro-bus had been completely destroyed and it would have been impossible for me to scrape off any of the old sticker to return to them.

Fortunately, our Pastor had another copy of his composition in his Parish office, so he did not suffer an irreplaceable loss. The insurance covered the cost of a used, blue Chevy station-wagon that lasted for many years and was later sold to a friend living in Washington, D.C., even if it did develop a hole in the floorboard that allowed water to be splashed onto the floor under the passenger seat.

I did discover that there probably had been a rough edge to the metal pipe leading from the gas line into the plastic tube of the combustion chamber of my destroyed micro-bus. When the ragged metal cut through the tubing, gasoline was squirted onto the hot motor. That was certainly as direct a means for burning up a vehicle as any other method. It was also very dramatic.

Oregonian Odds and Ends

Although my professional life in Corvallis, Oregon was the pits, living there was really quite pleasant, once a resident accepted the daily, light rainfall. The summers were dry, too dry, actually; drought was not uncommon at that time of the year. If possible, escape across the Coastals to the Pacific, or over the Cascades to the east, made existence much more pleasant. Corvallis’ heart of the valley location in the snow shadow of Mary’s Peak allowed only a minimal white cover during the winter months. There, was, however, a significant snowfall during our second winter. Deb was able to build an impressive snowman in our Highland Way backyard.

The only major environmental event during our stay in Oregon was the Good Friday Earthquake which devastated Anchorage, Alaska on the morning of March 27, 1964. I thought I had felt the duplex, where we were living at the time, shake slightly while I was eating breakfast at our kitchen table. It was not until I was on my way to my lab in the Science Research Institute that I saw the markings on the seismograph in the hallway display-case near the Geology office. I had noticed its scribbles each morning when I passed it, but, that day, the rapid wiggles were off the edges of the chart. Later, I learned that this was the recording for a 9.2 temblor, a magnitude making the Alaska quake to be the largest ever measured for the North American continent! I never felt any of the Californian quakes, which must have occurred while we were living in Oregon, but THIS one could not be ignored.

There were, also, minor family movements exhibited during our two years in Corvallis. Ken finally learned to crawl and walk. It took him awhile to move about on his knees, and later, on two feet. At a very early age, he had learned how to carry something in one hand, while using the other one to help bump his way across the floor on his padded butt. He had minimal need to walk on two legs when the butt-bump method provided all he required for daily movement around the house. Moreover, for his second Christmas, he received two horses: a brown spring-driven one for bouncing and a white one for sitting on while pushing. That was the Christmas when Debbie learned to cook, albeit on a large, cardboard stove. She specialized in pancakes and paper products.

Karen did go with Deb and Ken, on a very long train-ride, to visit her sister Tami and family in Los Angeles. They went to Knot’s Berry Farm, if not to Disney World. Our other trips were several to Seattle to visit Bob and Audry Ritchie, who were our friends from Hanover. Bob was now head of the Math department at the University of Washington. He claimed that from his office, each day, he photographed Mount Hood, which was visible more often than not. As a result of our visits, I believed Seattle might be the only large city where I could enjoy living. Never did, but I have liked every trip I’ve ever made there. Houston, Texas is certainly NOT Seattle!

Our social life in Corvallis was minimal. There may have been an occasional party with faculty from the Biochemistry department. No one ever arrived on time. There was one evening when we gave a party and received a telephone inquiry thirty minutes after it had been scheduled to begin. The caller wondered if they had the date correct. They had driven by our house on Jefferson and saw no one as they passed by. They, and others, arrived a short while later.

The usual way to gain new friends is through your own kids. Deb began attending kindergarten in Corvallis and became friends with a young Cy Field, whose great-grandfather had laid the first telephone cable under the Atlantic Ocean. Karen and Becky Field became somewhat close, if I recall, but there were no others she or I met on a recurring basis.

My professional life as a research biochemist held minimal pleasure; but there was an entertaining alternative. I completed my work on “Basic Biochemistry: A Programmed Textbook” for Basic Press. I had begun my efforts at Dartmouth, where the concept of a “programmed text” was being introduced. One of our friends in the Psychology department was preparing one for his own discipline and had introduced me to a representative from Basic Press. Strangely, I also recall that our friend was a Skinnerian, who actually raised his own son in a Skinner Box!

With regard to the concept of a programmed textbook, I might mention that, instead of reading a classic text composed of paragraphs, the student encounters a series of interrelated questions and statements, with fill-in-the-blank positions completing sentences within a specified block of text. The individual blocks are designed to follow predetermined, but alternative, pathways, dependent upon how the user fills-in-the-blank. The result is a “programmed text.” The method would, later, find application in computerized learning, in which jumping from one block to another is made much easier through the associated electronic presentations.

I sent off the finished manuscript to Basic Books, who gave me a thousand-dollar prepayment. The book was never published. The biochemical structures for carbohydrates, amino acids and steroids were judged to be too costly to print in the recurring forms the method required. It was difficult enough to reproduce them on a typewriter, or by hand with pen-and-ink drawings.

When I began the effort at Dartmouth, I had engaged an undergraduate student to help in the development of the statements I would need. He read each written question and, if he could not fill-in-the-blank correctly, I would write additional intermediate questions until he could complete the final statement correctly. This was the most important feature for this method of “programmed instruction.” The student could proceed at his own pace along the branches needed or omit those which were not needed.

Somewhere in my closet is a copy of the manuscript I completed more than sixty years ago, when I attempted to be a computer before computerization actually occurred! The experience led, in great part, to the development of my own teaching style. This may be the reason why, in later years when answering questions posed by my own kids, they were offered, at the outset, either the short or the long version. For the long answer, I would formulate intermediate questions they had to answer until they, themselves, reached the final solution to the question raised. Most of the time they wanted the short answer, the one we all routinely seek as we pursue the odds and ends in our own lives.

Thoughts about Washington, D.C.

At the time of Kennedy’s assassination, I did not realize how those events occurring in Washington, D.C. would affect my own life and career development. All I knew was that, within weeks of our arrival four months earlier, I could not remain at OSU. It was because of my distasteful work in Dr. King’s lab that I determined I must seek my future elsewhere. Over the following months, close faculty friends knew I was searching for a dramatic change in my academic life.

Shortly afterwards, a likely escape route was provided by Dr. Donald MacDonald, a young faculty member in the department. He had a friend, Dr. Bob Backus, who was an administrator with the National Institutes of Health, a federal agency known for its support of biomedical research through its grant-awarding functions. I met with Dr. Backus on one of his visits to the University and applied for a position in the NIH-supported “Grants Associates Program.”

This federal program was a new endeavor in which the agency would retrain active scientists to become scientist-administrators. The process was thought to be easier than making current administrators into scientists. These scientist-administrators would have an overview of the Nation’s expansion in biomedical research. My application had been favorably reviewed and approved. I was invited to Bethesda, Maryland, for a series of interviews for the GA Program and was accepted into the next available class. However, I needed to wait for the forthcoming federal budget cycle, beginning in July 1965.

Throughout my life, I had been very interested in teaching and believed that this was my most significant talent. I had enjoyed my interaction with students in segments of the biochemistry courses offered at both Dartmouth Med and Oregon State. The students, themselves, seemed to believe I was able to provide useful information about lipids, even though I, myself, felt this was not a significant part of the curriculum for biochemistry.

Although I enjoyed, more or less, working in the lab, I also felt my physical skills were only average and that I was not destined to be a lab-bench investigator forever. My preference would be to offer an entire biochemistry course at the undergraduate level, in some small college, if not a major university, where faculty membership is determined by what you publish rather than by what you teach. I never reached my goal.

Although an academic life as a faculty member had been in my plans for many years, I began to think, with other members of the biochemistry faculty at OSU encouraging me, that an alternative career in administration might fit my profile equally well. On the other hand, I was concerned how Dr. Wright and Dr. Smith would view such a change. They had mentored me to be an investigator, not an administrator. Working in a government agency might be only slightly preferable to a job in industry!

Nevertheless, my emotional life at OSU changed dramatically during the autumn of 1964, a year after Kennedy’s death, when I learned I would be leaving my “imprisonment” by Tsoo E. King. I looked forward with great anticipation to departing the oriental kingdom of which I had been a minor player and undertaking a more significant role in what had once been JFK’s Camelot. A lowly knight would be a vast improvement for the serf I had been. Although Camelot’s towers had vanished in the mists, I continued to hope new ones would be raised. If not Camelot, perhaps the Great Society would have a place for me. Washington, D.C. could become my new “heart of the valley.” Later, I learned Potomac Fever can be a welcomed remedy to Willamette Chills.

Flight to a New World

Christopher Paul was born in Corvallis, Oregon, on May 30, 1965, only five days after my own thirtieth birthday. Two weeks later the family began a new life which led us in a very different direction.

A month or so earlier, in mid-April, I made my first flight to Washington, D.C. to house-hunt before moving on to the annual biochemistry meeting in Atlantic City, New Jersey. The plane was a Boeing 727, the series which had made its maiden flight only two years earlier, in 1963. It was a strange, exciting experience to ride inside a javelin thrown into the sky. Technology said it should stay there, hurtling across the continent, but common sense said otherwise. Everyone knew, from the days of the Wright brothers, onward, that airplanes had propellers that moved the air rapidly over the wings to provide “lift” to the underside of them. They did not have jet engines mounted there instead. Somehow it worked.

I made my first landing in Washington, D.C., an event repeated often over the next five years. Each time there was the wonderment of seeing the Capital laid out beneath me. The Mall, the White House, the Washington Monument and the Lincoln Memorial were extremely exciting to view from a seat traveling several hundred feet above them. An early, evening arrival was even better, with the lights shining on each of the buildings erected to give a sense of solidarity to all who beheld them. I had a very early infection resulting in Potomac Fever that lasted for decades.

I was fortunate to find a perfect house only a few blocks from the campus of the National Institutes of Health (NIH) in Bethesda, Maryland. It was of modest Georgian style with old bricks, dormer windows and white trim. Of course, there was a cherry tree in the front yard. We could have it as a very inexpensive, semi-furnished rental for a year, while its owner, who was an officer with the United States Public Health Service (USPHS), was on an out-of-town assignment. The NIH was part of the USPHS, which, itself, was a division within the Department of Health, Education, and Welfare (DHEW). Welcome to the federal alphabet soup!

In mid-June, only a few weeks after Kip (the shortened version of Christopher Paul) was born, Karen and the three kids, Debbie, Ken, and Kip, had their own 727 adventures flying from Corvallis to Cleveland by way of Chicago. This was Karen’s first flight. It was, she maintains, adventurous enough for her. The plane was late arriving in Chicago. Ground assistants helped her with the three young kids, ages six years, two years and three weeks, race from one terminal to another. She has maintained that the businessmen on the flight to Cleveland readily made room for them. A telephone call from an airline agent alerted Karen’s father of the delay, since he was to have met them at the Cleveland airport for the drive to Sandusky where she would await my arrival.

The plan was for me to drive our recently purchased Chevy wagon to Ohio, meet the family, visit relatives, and drive on to Bethesda. The loading of our furniture onto a cross-country moving van would be supervised by our former, semi-willing landlords, the Messengers. Somehow it all worked out. Driving from Oregon to Ohio in a Chevy van was more comfortable than driving a VW van to the Pacific Northwest, as we had done only two years earlier. My escape from the secret kingdom of Tsoo E. King, to the Johnsonian administration made up for any hardships of the lonely drive.

A new world lay ahead of me. The days of academic studies and research would now become a time for learning about science administration. Now I would be supervising the giving of federal grants instead of trying to get them. It seemed as if this direction in my life, as well as in my geography, would be more fun, and maybe more exciting in a positive way.

Life on Cedar Lane

Cedar Lane was one of the major streets in Bethesda, Maryland. Our rental house was less than a mile from the main campus of the NIH and would have been an ideal location for getting to work, except the Grants Associates Program was in the Westwood Office Building on the far side of Bethesda. My daily commute was longer than I thought it would be when I first rented the house. However, the Westwood neighborhood was lined with as many cherry trees as there were around the Tidal Basin downtown. In springtime I had a magnificent drive through a variegated-pink tunnel which quickly gained a carpet of petals swirled by the passing of commuter cars.

My destination was not the Emerald City of Oz, although at times there was a mystical similarity. The Westwood Office Building housing many of the extramural programs of the NIH was the typical, privately built, elongated structure with pale-green offices leased to the federal government. No one knows the origin of that shade of civil-service green found in each two-room work site, public service areas, all hallways, and a basement cafeteria. The entrance space for each office was designed for a secretary and the adjoining private section for the level GS-10-or-above federal agent.

The major traffic problem associated with my drive to work was due to the location of Cedar lanes, itself. Since it was, indeed, one of the major streets leading into the NIH, the morning traffic was heavy. Every evening, I would enter our driveway in the usual manner, and every weeknight, I would back the car out of the driveway and reposition it so I would have a head-start in the morning. There was no way I could have backed out of the drive during the morning rush-hour, unless Karen stood in the middle of the street to stop the traffic, a “solution” neither of us desired.

Another interesting observation about our house was our backyard which was planted with bamboo. I soon learned how rapidly this alien plant grew and spread, unless I whacked it down as often as I could. We had a bed of strawberries which was much easier to maintain. My pile of grass clippings was not. I thought the mulch mixture would decompose over time. It did not. The smelly remains had to be bagged and carted off before the owner returned at the end of our rental year.

Our neighborhood was not far from a small park to which Karen could take the kids. There was not much else for them to do. During our year there, we met no one residing near us. Deb did begin her first grade at Holy Redeemer elementary school, which was in walking distance. Nevertheless, we did enjoy our first year of living in a non-academic town. Bethesda, itself, did not have much to offer, except for a restaurant which served an incredible version of mock-turtle soup. (Yes, it is strange what continues to be recalled from a half-century ago!)

Another event of that year in a new environment concerned my first hospitalization as an adult. It occurred during the Christmas season and has led me, ever since, to associate this holiday with hospitals. For some unknown reason, I fainted on Christmas morning. Karen and I decided I should check myself into the local Bethesda Suburban Hospital to see if a cause could be found. After several days of examinations, nothing definitive was diagnosed, even here in the center of health care for the nation. My physician, Dr. Herman, said I was a “normal, overweight, early-middle-aged executive” who should lose 40 – 50 pounds. It would also be best for me to give up smoking. He prescribed Valium, the current pill-of-choice for anxiety attacks, for the next few months. He also warned me I was “pre-diabetic,” which was a relatively new concept fifty years ago.

Whether it was stress or merely hypochondria resulting from my reading a Christmas present book which included descriptions of brain tumors, I never did discover. But I did learn I preferred to be engaged in becoming a biological science administrator and not a brain surgeon.

Becoming a Scientist-Administrator

My change of career from working in university research, writing for publication in scientific journals, and teaching biochemistry students about lipids to becoming a scientist-administrator on a national level was not as difficult as I had expected it might be. I enjoyed becoming an administrator while avoiding the usual result of becoming a bureaucrat. The difference between the two is that a bureaucrat learns the ways to say “no,” whereas an administrator, with the same information, knows how to say: “yes, it will work if you do it this way.” The other rule I tried to follow was: can I justify why I’ve chosen this administrative action if I had to explain it to Karen’s Ohio-Republican father?

The procedure I followed for learning how to become a scientist-administrator was through an internship program, the Grants Associate Program (GAP) of the NIH. The GAP had been initiated only two years previously (1963) with ten recruits. Although we did not comprise a formal class, most of the current dozen “GA’s” entered the program at the start of the federal fiscal year, which began, back then, on July 1. Over the years, the members of my class became close friends and colleagues. The NIH had hoped that this would be one of the results of this experience, since it was anticipated we would spread throughout the NIH and related agencies of the federal government. A successful program, ultimately, would be responsible for increased cooperation among all of the science-related components of the federal government.

My first intern-assignment was with the National Institute of Dental Research (NIDR). Its extramural grant program was located in a separate office building in downtown Bethesda. I remember riding up in the elevator, on my first morning of federal employment, with a black gentleman dapperly dressed in a dark suit and vest and carrying what looked like a neatly furled English bowler umbrella. We left the elevator at the same time and chatted as we walked down the corridor to the NIDR offices. When I asked where I might find Dr. Tom Malone, the Director of the extramural programs, he introduced himself as the person to whom I had been assigned. Tom was not quite the Irishman I had been expecting to meet. He would be my mentor for the next month. Over the following years, we became close friends and colleagues. He remained as one of my mentors as he, himself, advanced within the NIH.

I should mention, for the sake of clarity, that the NIH consists of multiple, independent Institutes, each of which may have intramural as well as extramural programs. The intramural programs, housed on the main campus of the NIH, employ their own scientists engaged directly in basic or clinical research focused on specific diseases or body organs, e.g., the National Cancer Institute or the National Heart Institute. Their extramural programs support biomedical research on a nationwide basis for studies conducted at universities, medical schools, hospitals and other off-campus sites through grants funded by each Institute. The GAPS was, organizationally, part of the extramural program of the Division of Research Grants (DRG) which served the entire NIH in the review of grants funded by the individual Institutes.

During my internship with the NIDR, I was assigned a project in which I was to identify the research topics the Institute supported in basic biochemistry. In 1965, computers and the data they held were in their infancy; in fact, they were neonates rather than toddlers. The National Library of Medicine, another part of the NIH, had large (room-sized!) computers which could be accessed only by their own experts. I made a request to the NLM to obtain the titles of all scientific articles having specific search-terms associated with dentistry or the mouth that had been funded by the NIH, according to the article’s self-reported source of support. (Each article published in a scientific journal was required to identify the federal agency which had supported the research.) One of the search terms I thought would be logical was “saliva.” Certainly, the NIH must have supported research involving this biological fluid bathing the mouth and the dentistry associated with it.

A week after I had made the inquiry, the NLM sent me a lengthy computer listing of the published articles containing any of the search terms I had included. Unfortunately, I had not specified that the articles should be limited to human beings. I quickly learned that the NIH and the NIDR had supported a significant amount of research associated with mosquito saliva! After all, malaria and yellow fever were the results of bites by these infected critters!

So it was, at an early stage in the retrieval of computerized data, that I learned the significance of inclusionary and exclusionary terms. A computer coughs out only what you ask for; so, the user must be very cautious in raising the right questions and using appropriate boundaries. Nevertheless, Tom Malone did like the final report I wrote for him and the National Institute of Dental Research.

Scientist-Administrator: NIH and DHEW

Assignments following my original NIDR experience were equally informative and fun for me as I continued to tour the NIH and other federal agencies. One effort was with the National Institute of General Medical Sciences (NIGMS) which provided extramural funds for basic biological and biochemical studies fundamental for all living conditions. Here my focus was on the method of support for the training of pre- and postdoctoral students through fellowships and training grants. The NIGMS also awarded grants for research, per se.

My research grant management exposure was obtained through an experience with the National Institute of Child Health and Human Development (HICHD), an agency resulting from an interest by the family of John F. Kennedy. New Institutes were constantly being formed or renamed depending upon current political conditions. Some referred to these changes being the result of the “disease-of-the-month club.” However, the re-designation of an Institute, or an increase in the funding for an existing one, normally required that the “fad” exist through a federal budget cycle or two before the result to become final.

In addition to exposures within the Institutes, I also had an assignment with the Division of Research Grants. The DRG interacted with all of the Institutes, since it was the centralized organization for the peer review of all requests for funding by the NIH. Here were the “study sections” headed by chiefs who were administratively in charge of each review group, composed of outside consultants from academic and research centers throughout the nation. Three or four times a year, each group, consisting of ten to twenty members, gathered in Bethesda to review all applications coming from those seeking support through research grants, fellowships, training grant programs or large “program projects,” which incorporated funds for both research and training in a specified area.

The members of each review group (study section) would have read the applications prior to attendance at their meeting, where they would, after further discussions, vote a “priority score” as an assessment of the merit of the request being made. Applications with voted scores between 100 and 200 – with 500 being the poorest, yet approved, score – might be funded by one of the Institutes for which the reviews were made. The final decision to support an approved application depended upon the budget for each Institute, to which the grant proposal had been assigned by the DRG. During the period of tight budgets allocated to the NIH by Congress, awards might be limited to those with scores between 100 and 150. Only those requests with the very best priority scores were ever funded.

In addition to internship assignments with the Institutes and the DRG, I also had an opportunity to observe events involving overall policies of the NIH. At that time, Dr. John Sherman, who was a legendary director for the NIH extramural programs, requested that I draft serval documents for his consideration while I was assigned to “Building One” of the NIH.

My month-long assignment to the Office of the Secretary of the Department of Health, Education and Welfare offered me a different kind of opportunity. Since the DHEW was in downtown Washington, D.C. I had time, during my lunch periods, to visit sites of interest around The Mall. This was an era when the Capitol was open to all citizens. If a person looked like he belonged, it was possible to roam the halls of Congress without any security badge or other approval. I had learned the technique of walking-rapidly-with-purpose and saw a lot of new territory that now would be completely “off-limits” due to new terrorists. What a difference can be made by the exchange of a few letters like “– itory” and “– orist!” when appended to the basic: terri/terro!